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Medically reviewed by Drugs. Last updated on Nov 2, Spironolactone is used in combination with other medicines to treat high blood pressure hypertension and heart failure. Lowering blood pressure can reduce the risk of strokes and heart attacks.

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Spironolactone (Oral)

Spironolactonesold under the brand name Aldactone among others, is a medication that is primarily used to treat fluid build-up due to heart failureliver scarringor kidney disease. Common side effects include electrolyte abnormalitiesparticularly high blood potassiumnausea, vomiting, headache, rashes, and a decreased desire for sex. Spironolactone was discovered in and was introduced in Spironolactone is used primarily to treat heart failureedematous conditions such as nephrotic syndrome or ascites in people with liver diseaseessential hypertensionlow blood levels of potassiumsecondary hyperaldosteronism such as occurs with liver cirrhosisand Conn's syndrome primary hyperaldosteronism.

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Oral Spironolactone in Post-teenage Female Patients with Acne Vulgaris

Drug information provided by: IBM Micromedex. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

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Studies dating back to the s have demonstrated the efficacy of spironolactone for acne in women, particularly acne unresponsive to nonhormonal therapies. However, the drug comes with an FDA-mandated black-box warning about tumorigenic potential and the caution that "Unnecessary use of this drug should be avoided. Spironolactone also is contraindicated in patients with renal insufficiency, pregnancy, abnormal uterine bleeding, estrogen-dependent malignancy, and in combination with drugs that could lead to hyperkalemia. Keeping the safety issues at the forefront, spironolactone has well documented efficacy in difficult cases of acne, Bethanee J.